Authors: Leinwand, Kristina L. DO; Gerich, Mark E. MD; Hoffenberg, Edward J. MD; Collins, Colm B. PhD; National Institutes of Health T32 Institutional Training Grant in Pediatric Gastroenterology; National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health; Colorado Department of Public Health and Environment

All content at Best Choice Reviews concerning CBD (Cannabidiol) or other health related matters are for informational purposes only and are not to be considered as a substitute for medical advice, diagnosis, or treatment. If a reader has further questions about the use of these products, we encourage them to consult with a licensed physician or other qualified health care provider. The information included here is for informational purposes only and Best Choice Reviews is not responsible for inappropriate use of these products.
When administered alone, CBD is an effective anticonvulsant in maximal electrical shock (MES), magnesium-free, 4-aminopyridine, and audiogenic models (7, 8). Co-administration with AEDs leads to various effects; anticonvulsant effects of CBD are enhanced with phenytoin or phenobarbital but decreased with chlordiazepoxide, clonazepam, trimethadione, and ethosuximide. In a recent study using an acute pilocarpine model, although CBD administration reduced the number of animals displaying seizure activity, CBD did not appear to have any significant effect on the number of seizures per animal (7).

CBD was also found to disrupt the consolidation of generalized fear memories when administered immediately after the acquisition of such fear memory. Interestingly, the timing of the administration of CBD was vital as the results demonstrated that delayed administration of the CBD dose did not have the same effective result that immediate administration did.


BioBloom is the only organic CBD oil manufacturer that conducts meticulous lab tests to ensure its formulas contain a near-perfect 50:50 CBD to CBDa ratio. There’s a large body of research pointing to the benefits of Cannabidiol being enhanced by the presence of its counterpart (its acid form) CBDa. If you want this added benefit when taking other brands, try purchasing some hemp tea, where the CBDa content is naturally higher. Moreover, BioBloom drops are whole-plant extracts, meaning they contain not only a full spectrum of cannabinoids, but also the often-lost lipids, chlorophyll, terpenes, bioflavonoids and other delicate phytonutrients present in Cannabis Sativa L. This is why the colour of the oil is darker and the taste stronger.
To make matters more confusing, nine states (including California, Washington, and Colorado) let residents buy cannabis-based products with or without THC. Nearly two dozen other “medical marijuana states” allow the sale of cannabis, including capsules, tinctures, and other items containing CBD or THC, at licensed dispensaries to people whose doctors have certified that they have an approved condition (the list varies by state but includes chronic pain, PTSD, cancer, autism, Crohn’s disease, and multiple sclerosis). Sixteen more states legalized CBD for certain diseases.
Alicia Salazar, a New York state board certified health coach, uses CBD with her clients to maximize their health outcomes. “I don’t look at CBD as a magic bullet for weight loss,” she said. “But CBD along with a healthy diet – one that contains healthy fats, whole grains, grass-fed meat and dairy, and plenty of greens, without processed foods and sugar – sets the tone for a healthy weight. And for some, that can naturally include weight loss.”
CBD hemp oil has a number of uses and comes in many forms including capsules, tinctures, sublingual supplements, liquid oil, oil as a paste, sprays, salves, creams and in edible forms, such as candies or sweets. You can also inhale CBD oil from vapor-releasing pens, similar to the technology for e-cigarettes. This variety also provides a lot of controlled flexibility in terms of concentration, making CBD hemp oil useful and desirable for people of all ages, economic means, and personal needs.
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Bluebird Botanicals is a liquid extract oil blend. It contains a variety of hemp extracts. This formulation includes both CBDa (non-decarboxylated) and CBD (decarboxylated) forms of cannabinoids using a 1:1 ratio. The hemp extract is steam distilled which ensures that all the beneficial terpenes remain intact. It also contains a variety of ketones, aldehydes, and organic extra virgin olive oil.
Although CBD oils aren’t regulated by the FDA, purchasing products stateside from one of the nine states where recreational and medical cannabis use is legal will likely result in a higher-quality product than buying one made with hemp-derived CBD oil imported from abroad, says Martin Lee, director of Project CBD, a nonprofit that promotes medical research into CBD.
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