Thank you for your questions. Marijuana and hemp are two extremely different strains of the same cannabis sativa plant that have been bred over thousands of years to have entirely different purposes. (Hemp is not the male version of the marijuana plant.) They both contain CBD. Hemp only contains CBD whereas marijuana contains CBD and perhaps a hundred or so other chemicals with a variety of functions, such as THC, the molecule that makes people “high”. Any medicine can have different effects on different people. For example, Benadryl makes some people sleepy yet can make others wide-awake. So, it is not inconsistent for a particular medicine to cause a symptom in one person and to help alleviate it in another. So while many people experience relaxation with CBD, so people do experience the “paradoxical” effect of irritability.
While overstimulation of the CB1 receptor may lead to symptoms such as high blood pressure and abnormally high cholesterol levels, CBD is a CB1 antagonist, so it is not likely to cause such issues. Furthermore, the World Health Organization has recently issued a global report on CBD, claiming that it has a good safety profile and minimal adverse public health effects.
Scam CBD sellers tend to manufacture low-grade oils via ethanol (or other solvent-based) extraction, in what is little better than trying to do it yourself in your basement. The result is a liquid that contains a little CBD (along with some other cannabinoids and terpenes), but not in the quantities needed to be effective in terms of any legitimate medicinal function. Moreover, these solvent-based extracts can contain unnecessary and potentially harmful components — after all, scam artists are not going to reveal the REAL ingredients, are they?
The previously mentioned study which established improved mitochondrial function with CBD use also observed that CBD stimulates gene expression within white fat cells. This initiates the “browning” of these cells. This mechanism shows promise with converting hard-to-lose white fat into a more easily burnable form. Additionally, researchers found that CBD decreased the rate of new fat cell creation.
All in all, current research shows us that we will experience the most significant degree of therapeutic relief when all the cannabinoids and the terpenes — essential oils that produce the plant’s aromas — are in the oil. Even adding just a little THC in CBD oil can greatly improve the medical properties because of the phenomenon known as the entourage effect.