These reports suffered from a number of design flaws, including incomplete baseline quantification of baseline seizure frequency, indeterminate time periods for outcome determination and, in some cases, inadequate (or missing) statistical analysis—in general, a lack of sufficient detail to adequately evaluate and interpret the findings. Limitations aside, several studies did report that administration of adjunctive CBD did not result in meaningful changes in seizure frequency (11–13).
The Love Hemp CBD water range is also extremely popular, with 500ml bottles selling for just £1.99. This is CBD-infused water, to be clear, and Love Hemp claims the formulation took nine months’ worth of research from its Research and Development team. It basically tastes like mineral water, and is a great way to get your CBD intake on the move and stay hydrated at the same time.
Populum’s CBD oil utilizes a full-spectrum of cannabinoids. It has a subtle orange flavor and contains antioxidants, natural ingredients, and neuroprotectants. It is free from GMOs and gluten. The label shows that this product is made with several oils in addition to hemp oil, including grapeseed, orange, and virgin coconut oils. It also contains stevia extract for a sweet flavor.
Even though high-strength CBD oils are more expensive than lower concentrates, they work out to be more cost-effective and longer-lasting because you’ll need fewer drops to obtain the same effect. For example, a single drop of Love Hemp’s 40% CBD oil contains 20mg of CBD, that is 4 times more than a 10% tincture, which provides just 5mg per drop. If you’re looking to take a high dose, stronger concentrates will also make it easier to achieve your desired dose (fewer drops to count!).
Side effects of CBD include nausea, fatigue and irritability. CBD can increase the level in your blood of the blood thinner coumadin, and it can raise levels of certain other medications in your blood by the exact same mechanism that grapefruit juice does. A significant safety concern with CBD is that it is primarily marketed and sold as a supplement, not a medication. Currently, the FDA does not regulate the safety and purity of dietary supplements. So you cannot know for sure that the product you buy has active ingredients at the dose listed on the label. In addition, the product may contain other (unknown) elements. We also don’t know the most effective therapeutic dose of CBD for any particular medical condition.
While animal experimental data clearly suggest a potential benefit, supportive clinical data are quite sparse. In a case-control study of 308 cases of new onset seizures, Brust and colleagues found that marijuana use was significantly less prevalent among men who had unprovoked seizures compared to case controls (9). This difference was not significant in women. The authors suggest a potential protective effect against seizures with marijuana use; however, this should be considered speculative.
CBD may offer an option for treating different types of chronic pain. A study from the European Journal of Pain showed, using an animal model, CBD applied on the skin could help lower pain and inflammation due to arthritis. Another study demonstrated the mechanism by which CBD inhibits inflammatory and neuropathic pain, two of the most difficult types of chronic pain to treat. More study in humans is needed in this area to substantiate the claims of CBD proponents about pain control.
If you live in a state where CBD is legal for your condition, it’s best to buy it from a state-regulated dispensary. But even there, oversight is uneven. “I feel safe being a cannabis consumer in Colorado, since the state tracks everything from seed to sale, but I didn’t the first few years after cannabis became legal,” when the rules were still taking shape, says Robyn Griggs Lawrence, the Boulder author of The Cannabis Kitchen Cookbook, which features recipes for cannabis edibles.
Furthermore, a study published in the Journal of Neuroendocrinology has suggested that the ECS is capable of stimulating specific areas of the body involved in metabolism, such as the skeletal muscles and GI tract. This happens due to the presence of anandamide and 2-AG, which are two naturally-occurring compounds in the body that interact with the CB1 and CB2 receptors.
Although CBD oils aren’t regulated by the FDA, purchasing products stateside from one of the nine states where recreational and medical cannabis use is legal will likely result in a higher-quality product than buying one made with hemp-derived CBD oil imported from abroad, says Martin Lee, director of Project CBD, a nonprofit that promotes medical research into CBD.